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“Our target is to be familiar with female reproductive ageing, and why fertility swiftly declines setting up in the mid-30s,” claims Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata will work.

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Munakata and Namekawa will Assess mice with usual and mutated variations of the chromatin remodeler. Since the mice improve and experienced, they'll observe whether the presence or absence of the protein triggers dissimilarities during the arrangement of DNA spools inside the animals’ oocytes. And they're going to check no matter whether this, subsequently, alters the sample of gene expression eventually.

Each one includes a mass of thread-like DNA — akin to website 400 miles of yarn. To keep it from devolving into a tangle, the DNA is wrapped around a series of protein spools, called nucleosomes.

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